PRE-ACTIVATED FOR SUPERIOR ABSORPTION - This very powerful B vitamin combination supplies most of the B vitamins in their coenzymated forms, promoting optimal bioavailability.* NATURALLY-OCCURING FOLATES - B-Supreme contains Designs for Health's proprietary NatureFolate blend of naturally-occurring folates. * SYNERGISTIC FORMULA - TMG and choline are included to support methylation. B-Supreme also includes the methylated form of B12 (Methylcobalamin), and the active from of B6 as P-5-P.* HIGHER STANDARDS. BETTER RESULTS - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut corners with substandard ingredients. This product is Non-GMO, Gluten-Free, and Vegetarian-friendly. OVER 50,000 DOCTORS AGREE - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.